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Image Search Results
Journal: bioRxiv
Article Title: Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes
doi: 10.64898/2026.01.07.697832
Figure Lengend Snippet: Differential gene expression in progressors (biopsy 1) and non-progressors (biopsy 1) within PanCK-positive (A-C) and PanCK-negative (D) regions of interest (ROI). (A) Heatmap depicting unsupervised clustering of samples into two groups based on differentially expressed (DE) genes. (B) Volcano plot highlighting significantly DE genes with yellow dots. (C) Violin plots illustrating the most prominently downregulated gene (CDKN2A) and upregulated gene (STOM) in progressing oral epithelial dysplasia (OED). (D) Volcano plot displaying significantly DE genes with yellow dots, alongside violin plots showing downregulated genes (S100A10 and KL4) and upregulated gene (ZFAT) in progressing OED.
Article Snippet: Slide preparation was performed according to the manufacturer’s protocol (Nanostring GeoMx) with the following digestion and heat-induced epitope retrieval (HIER) conditions: 0.1 μg/ml Proteinase K for 15 min and ER for 20 min. ROI selection (PanCK+/PanCK-) was performed in the GeoMx Digital Spatial Profiler (DSP) based on morphology and
Techniques: Gene Expression
Journal: bioRxiv
Article Title: Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes
doi: 10.64898/2026.01.07.697832
Figure Lengend Snippet: (A) Bar graph showing the most enriched pathways in Progressors, indicating the number of enriched pathways within each category. (B) Heatmap illustrating clustering of PanCK-positive (PanCK+) regions of interest (ROI) in progressing and non-progressing oral epithelial dysplasia (OED). (C) Volcano plot displaying differentially expressed (DE) pathways, with yellow dots representing significant pathways in PanCK+ ROI of progressors and non-progressors. (D) Heatmap showing clustering of PanCK-negative (PanCK-) ROI in progressing and non-progressing OED. (E) Heatmap illustrating clustering of PanCK+ ROI in precursor lesions and subsequent oral squamous cell carcinoma (OSCC) samples. (F) Heatmap depicting clustering of PanCK- ROI in precursor lesions and subsequent OSCC samples. (G) Volcano plot with yellow dots indicating DE pathways in PanCK+ ROI of precursor lesions and subsequent OSCC.
Article Snippet: Slide preparation was performed according to the manufacturer’s protocol (Nanostring GeoMx) with the following digestion and heat-induced epitope retrieval (HIER) conditions: 0.1 μg/ml Proteinase K for 15 min and ER for 20 min. ROI selection (PanCK+/PanCK-) was performed in the GeoMx Digital Spatial Profiler (DSP) based on morphology and
Techniques: